SNIPER(ER)-87 Catalog No.:M7563-10 4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile

4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrile

Formula: C21H22ClNO4

) in a model of puromycin aminonucleoside-induced renal fibrosis

Entrectinib potently blocks proliferation of Ba/F3-TEL-TRKB (IC50 of 2

SNIPER(ER)-87 Catalog No.:M7563-10 4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)pyrimidin-2-yl)amino)ethyl)amino)nicotinonitrileSNIPER(ER) 87 is a potent and selective estrogen receptor (ER) Degrader (Specific and Nongenetic IAP dependent Protein Erasers or SNIPER) (DC50 = 3 nM). SNIPER(ER) 87 comprises the IAP binding ligand LCL 161 (Cat. No. 7178) joined by a linker to the estrogen binding moiety 4 hydroxytamoxifen (Cat. No. 3412). The product decreases ER levels in breast cancer cells in vitro and in mouse ovaries in vivo. SNIPER(ER) 87 also reduces ER levels and inhibits