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InChiKey: DZHFTEDSQFPDPP-HWYNEVGZSA-L
Lapveteläinen T
Regulated necrosis and its implications in toxicology
12(24):2727-40
TraMetinib - CAS# 871700-17-3 0201 InChiKey: DZHFTEDSQFPDPP-HWYNEVGZSA-LTrametinib, also known as GSK1120212, CAS No. 871700 17 3, is a n orally bioavailable inhibitor of mitogen activated protein kinase kinase (MEK MAPK ERK kinase) with potential antineoplastic activity. Trametinib specifically binds to and inhibits MEK 1 and 2, resulting in an inhibition of growth factor mediated cell signaling and cellular proliferation in various cancers. MEK 1 and 2, dual specificity threonine tyrosine kinases often upregulated in
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