XMD8-92 mterene KRCA-0008 is a potent dual

KRCA-0008 is a potent dual inhibitor of Ack1 and anaplastic lymphoma kinase (ALK)

1-9H3/t22-

(2013) J Am Chem Soc

Smiles: C#CCC(CC1=CN=C2N=C(N)N=C(N)C2=N1)C1C=CC(=CC=1)C(=O)N[C@@H](CCC(O)=O)C(O)=O

XMD8-92 mterene KRCA-0008 is a potent dualXMD8 92 is an ERK5 BMK1 inhibitor and also BRD4 inhibitor. XMD8 92 inhibits pancreatic tumor xenograft growth via a DCLK1 dependent mechanism. XMD8 92 blocks cellular BMK1 activation and significantly suppresses tumor growth in lung and cervical tumor models and is well tolerated in animals. Product information CAS Number: 1234480 50 2 Molecular Weight: 474. 55 Formula: C26H30N6O3 Chemical Name: 5 {[2 ethoxy 4 (4 hydroxypiperidin 1 yl)phenyl]amino}