Nalfurafine 061PEG17-Hydrazide 2-trifluoroacetamido)butanoyl]-6

2-trifluoroacetamido)butanoyl]-6

The vitamin K antagonist Coumetarol is effective in both models after oral treatment but inhibits the thrombus formation more strongly in the arterio-venous shunt model

with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays)

18-13)19-20-15/h8-13

Nalfurafine 061PEG17-Hydrazide 2-trifluoroacetamido)butanoyl]-6Nalfurafine (TRK 820) is a potent selective and orally active G protein biased kappa opioid receptor (KOR) agonist with high translational potential. Nalfurafine (TRK 820) enhances the therapeutic potential of MOR targeting analgesics, has the potential for uremic pruritis treatment. Product information CAS Number: 152657 84 6 Molecular Weight: 476. 56 Formula: C28H32N2O5 Chemical Name: (2E) N [(1S,5R,13R,14R,17S) 4 (cyclopropylmethyl) 10,17 dihydroxy