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Salovska B
CPI-455 mediated KDM5 inhibition
LY2835219 specifically inhibits CDK4 and 6
A phase I/Ib study of trametinib (GSK1120212) alone and in combination with gemcitabine in Japanese patients with advanced solid tumors
E-7449 - CAS# 1140964-99-3 0290 Salovska BE 7449, also known as 2X 121, CAS No. 1140964 99 3, is an orally available small molecule inhibitor of the nuclear enzymes poly (ADP ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, E 7449 selectively binds to PARP 1 and 2, thereby preventing the repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of single and double strand DNA breaks and promotes
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