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Tyk2-IN-5 ino pyrazole Smiles: CC(C)(C)[Si](C)(C)OC[C@H]1O[C@H](C[C@@H]1O)N1C=NC2C1=NC=NC=2NC(=O)C1C=CC=CC=1

SKU: 53692465155

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Description

Smiles: CC(C)(C)[Si](C)(C)OC[C@H]1O[C@H](C[C@@H]1O)N1C=NC2C1=NC=NC=2NC(=O)C1C=CC=CC=1

) treatment significantly reduces the tumor growth in human lung cancer xenograft model

3-c]pyridin-5-yl)-3-(benzyloxy)-1-oxopropan-2-yl)-2-methylpropanamide (2R

Liarozole (40 mg/kg

Tyk2-IN-5 ino pyrazole Smiles: CC(C)(C)[Si](C)(C)OC[C@H]1O[C@H](C[C@@H]1O)N1C=NC2C1=NC=NC=2NC(=O)C1C=CC=CC=1Tyk2 IN 5 (compound 6) is a highly potent, selective and orally active Tyk2 inhibitor and targets the JH2 domain, with a Ki of 0. 086 nM for Tyk2 JH2 and an IC50 of 25 nM for IFN. Highly effective in inhibiting IFN production in a rat pharmacodynamics model and fully efficacious in a rat adjuvant arthritis model. Product information CAS Number: 1797432 62 2 Molecular Weight: 434. 43 Formula: C21H19FN8O2 Chemical Name: N [(1R,2S) 2 fluorocyclopropyl] 8

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