N-Desmethyltamoxifen hydrochloride - CAS# 15917-65-4 0273 2(6):1492-7

Name: N-Desmethyltamoxifen hydrochloride - CAS# 15917-65-4 0273 2(6):1492-7
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Description

2(6):1492-7

PubMed PMID: 23743261

prevention of blood-brain barrier opening

Nakanishi A

N-Desmethyltamoxifen hydrochloride - CAS# 15917-65-4 0273 2(6):1492-7N Desmethyltamoxifen hydrochloride, CAS No. 15917 65 4, is the major metabolite of tamoxifen in humans. N Desmethyltamoxifen, a poor antiestrogen, is a ten fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation. Product information CAS Number: 15917 65 4

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