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Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39
GW-7647 (50 nM) enhances the initial phase of Ca2+-regulated exocytotic events stimulated by ACh in antral mucous cells
5-dihydropyrazolo[5
eIF4B phosphorylation by pim kinases plays a critical role in cellular transformation by Abl oncogenes
GSK-2606414 - CAS# 1337531-36-8 0435 Target identification for a HedgehogGSK 2606414, CAS No. 1337531 36 8, is an orally available, potent, and selective PERK inhibitor. GSK 2606414 inhibits PERK activation in cells and inhibits the growth of a human tumor xenograft in mice. Protein kinase R (PKR) like endoplasmic reticulum kinase (PERK) is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states. Evidence that PERK is implicated in tumorigenesis and cancer cell survival
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