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inhibition of the overall reaction was found to be competitive with the allosteric activator of this enzyme
Retro-2 cycl (RN 1-001) inhibits JCPyV and HPV16 pseudovirus with IC50s of 54 μM and 160 μM
Smiles: FC(F)(F)C1C=C(N=C2C=1C=CC1=NC(=CN12)C1=NN=CO1)C(F)(F)F
52(9):2971-8
ARP 101 Catalog No.:M23013-C inhibition of the overall reactionARP 101 is a selective MMP 2 inhibitor with IC50 value of 0. 81nM. MMP 2 is an enzyme and involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction and tissue remodeling, as well as in disease processes, such as arthritis and metastasis . ARP 101 shows inhibition of fibrosarcoma HT1080 cell growth in vitro. ARP 101 has shown ~250 fold selectivity of MMP 2 over MMP 1 and ~100 fold
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