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on LPS-hyporesponsiveness
(2002) Blood
CAS Number: 670220-88-9
Affinity pulldown and kinase profiling studies implicate Erb3 binding protein-1 and the IκB kinase pathway in the mechanism of action of WS6
HG-10-102-01 - LRRK2 Inhibitor. CAS# 1351758-81-0 60293 on LPS-hyporesponsivenessHG 10 102 01, CAS No. 1351758 81 0, is a brain penetrant, potent and selective inhibitor of wild type LRRK2 and the G2019S mutant (IC50 for LRRK2 wild type ~20. 3 nM and LRRK2 [G2019S] ~3. 2 nM). It significantly inhibits Ser910 and Ser935 phosphorylation of both wild type LRRK2 and G2019S mutant at a concentration of 0. 10. 3 M in cells. HG 10 102 01 is the first compound reported to be capable of inhibiting Ser910 and Ser935 phosphorylation in mouse
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