Volasertib Catalog No.:M10873-10 Smiles: O=C1NN=C2NC(CN3CC4=CC=CC=C4C3)=NC3=CC=CC1=C32

Smiles: O=C1NN=C2NC(CN3CC4=CC=CC=C4C3)=NC3=CC=CC1=C32

2017 Jan 6

Ibuprofen is more efficacious than aspirin and acetaminophen

Smiles: CC(C)[C@@H](C)[C@@H](O)[C@H](O)[C@@H](C)[C@H]1CC[C@H]2[C@@H]3COC(=O)[C@H]4C[C@H](O)[C@H](O)C[C@]4(C)[C@H]3CC[C@@]21C

Volasertib Catalog No.:M10873-10 Smiles: O=C1NN=C2NC(CN3CC4=CC=CC=C4C3)=NC3=CC=CC1=C32Volasertib, also known as BI 6727, is a dihydropteridinone Polo like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. BI 6727 selectively inhibits Plk1, inducing selective G2 M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. BI 6727 is highly potent (enzyme IC(50) = 0. 87 nmol L, EC(50) = 11 37 nmol L on a panel of cancer cell