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101(11):2387-93
48 hours) and VS-5584 treatment causes significant induction of cell death in human pancreatic cancer (HPAC) cells in PDAC cell lines BxPC-3
InChi: InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6
attenuates magnetic resonance BOLD signals in brain of anesthetized mice: evidence of a link between neuron NAAG release and hyperemia
CFI-402257 - MPS1/TTK inhibitor. CAS# 1610759-22-2 Catalog No.:M6548-2 101(11):2387-93CFI 402257, CAS No. 1610759 22 2, is an orally bioavailable inhibitor of monopolar spindle 1 (MPS1 TTK) kinase (IC50 = 1. 7 nM). CFI 402257 is selective for MPS1 TTK over a panel of 262 kinases at a concentration of 1 M. CFI 402257 increases aneuploidy in HCT116 cells when used at concentrations greater than 100 nM. It inhibits cell growth in a panel of breast, ovarian, prostate, pancreatic, lung, and colon cancer cell lines (GI50s = 0. 001 1. 3 M).
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