Diclofenac sodium (DSS) Although ineffective to inhibit the

Although ineffective to inhibit the growth of UMUC-3 and ACHN cells in vitro (IC50s of 1

2077980-83-5

InChi: InChI=1S/C6H12F2N2O2/c7-4(8)6(10

increases early and late apoptosis

Diclofenac sodium (DSS) Although ineffective to inhibit theDiclofenac is a nonsteroidal anti inflammatory drug (NSAID) taken or applied to reduce inflammation and as an analgesic reducing pain in certain conditions. Diclofenac binds and chelates both isoforms of cyclooxygenase (COX 1 and 2), thereby blocking the conversion of arachidonic acid to pro inflammatory proprostaglandins. This agent also may inhibit COX 2 mediated tumor angiogenesis. When inhibiting COX 2, Diclofenac may be effective in relieving