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InChi: InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3
It shows accelerated FRAP recovery at 1 µM in the BRPF2 FRAP assay preventing binding of full-length BRPF2 to chromatin
CAS Number: 912545-86-9
12 cells (EC50 ~ 4 nM) and RS4
WYE-125132 Size:2mg solid InChi: InChI=1S/C10H13N5O4/c1-5-3-15(10(18)12-9(5)17)8-2-6(13-14-11)7(4-16)19-8/h3WYE 125132, also known as WYE 132, is a highly potent, ATP competitive, and specific mTOR kinase inhibitor (IC(50): 0. 19 + 0. 07 nmol L; >5, 000 fold selective versus PI3Ks). WYE 132 inhibited mTORC1 and mTORC2 in diverse cancer models in vitro and in vivo. Importantly, consistent with genetic ablation of mTORC2, WYE 132 targeted P AKT(S473) and AKT function without significantly reducing the steady state level of the PI3K PDK1 activity biomarker P
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