AZD6244 (Selumetinib) - MEK Inhibitor. CAS# 606143-52-6 0192 2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-(3-metho xyphenyl)-2-propanyl]acetamide (AZD-5423)

2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-(3-metho xyphenyl)-2-propanyl]acetamide (AZD-5423)

is a small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing

E-7449 is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2

Suppression of the clinical and cytokine response to endotoxin by RWJ-67657

AZD6244 (Selumetinib) - MEK Inhibitor. CAS# 606143-52-6 0192 2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-(3-metho xyphenyl)-2-propanyl]acetamide (AZD-5423)AZD6244, CAS No. 606143 52 6, (Selumetinib, ARRY 142886) is an orally active, highly potent and selective non ATP competitive MEK inhibitor, inhibiting MEK1 with an IC50 of 14 nM. In vitro cell viability inhibition screening of a tumor cell line panel found that cell lines harboring BRAF or RAS mutations were more likely to be sensitive to AZD6244. Treatment of primary HCC cells with AZD6244 led to growth inhibition, caspase 3 and caspase 7