PI3K/mTOR Inhibitor-1 306 (TsOH) Smiles: CN([C@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](CC1C=CC=CC=1)C(O)=O)OC)[C@@H](C)CC)C(=O)[C@@H](NC(=O)[C@]1(C)CCCN1C(=O)CCOCCOCCOCCOCCOCCOCCN)C(C)C

Smiles: CN([C@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](CC1C=CC=CC=1)C(O)=O)OC)[C@@H](C)CC)C(=O)[C@@H](NC(=O)[C@]1(C)CCCN1C(=O)CCOCCOCCOCCOCCOCCOCCN)C(C)C

7 nM (PIM3)

InChiKey: ULZFTGWWPHYLGI-RBZFPXEDSA-N

and SW620 cells with IC50s of 1

PI3K/mTOR Inhibitor-1 306 (TsOH) Smiles: CN([C@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](CC1C=CC=CC=1)C(O)=O)OC)[C@@H](C)CC)C(=O)[C@@H](NC(=O)[C@]1(C)CCCN1C(=O)CCOCCOCCOCCOCCOCCOCCN)C(C)CPI3K mTOR Inhibitor 1 is a potent, orally bioavailable dual PI3K mTOR inhibitor with IC50s of 20 376 204 46 nM and 186 nM for PI3K PI3K PI3K PI3K and mTOR, respectively. Antitumor activity. Product information CAS Number: 1949802 49 6 Molecular Weight: 407. 46 Formula: C18H22FN5O3S Chemical Name: 4 fluoro 5 [6 (1 methanesulfonylcyclopropyl) 2 [(3S) 3 methylmorpholin 4 yl]pyrimidin 4 yl]pyridin 2 amine Smiles: