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Berkofsky-Fessler W
24)36-21(31)10-8-2)12-17(14-29)13-26(33)19(27)11-15(3)23(26)32/h11-12
Formula: C8H14Cl2N4S3
20-lyase inhibitor abiraterone acetate (CB7630) in patients with prostate cancer
AMD-070 Catalog No.:M10820-10 Berkofsky-Fessler WMavorixafor, also known as AMD11070, AMD070, X4P 001, is an orally bioavailable and potent CXCR4 inhibitor. AMD11070 is an antagonist of SDF 1 ligand binding (IC50 = 12. 5 1. 3 nM), inhibits SDF 1 mediated calcium flux (IC50 = 9. 0 2. 0 nM) and SDF 1 mediated activation of the CXCR4 receptor as measured by a Eu GTP binding assay (IC50 =39. 8 2. 5 nM) or a [(35)S] GTPS binding assay (IC50 =19. 0 4. 1 nM), and inhibits SDF 1 stimulated chemotaxis (IC50
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