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25)14-4-2-1-3-5-14)12-17(16)29(26
shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice
Both GTS-21 itself and its demethylated active metabolite 4-OH-GTS-21 display nootropic and neuroprotective effects
Formula: C11H14N2O4
IWR-1 - CAS# 1127442-82-3 60189 25)14-4-2-1-3-5-14)12-17(16)29(26IWR 1, also known as IWR 1 endo, CAS No. 1127442 82 3, is a an inhibitor of the Wnt signaling cascade through inhibiting TNKSs, binding only to the adenosine binding site. IWR 1 inhibits epithelial mesenchymal transition of colorectal cancer cells through suppressing Wnt catenin signaling as well as survivin expression. IWR 1 inhibits cell proliferation and EMT even in the presence of TNF induced cancer cell stimulation. IWR 1 also significantly
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