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Chemical Name: 4-(4-((dimethylamino)methyl)-3
It inhibited Hh signaling and induces tumor regression in animal models of medulloblastoma
Connolly EC
InChiKey: SPTWXRJNCFIDRQ-ZHACJKMWSA-N
CASIN - Cdc42 Inhibitor. CAS# 425399-05-9 size:2 mg solid Chemical Name: 4-(4-((dimethylamino)methyl)-3CASIN, CAS No. 425399 05 9, is a novel and potent Cdc42 inhibitor with an IC50 ~2 M. In a recent publication in Cell Stem Cell, the elevated activity of the small RhoGTPase Cdc42 in aged HSCs was shown to be causally linked to HSC aging and correlate with a loss of polarity in aged HSCs. CASIN as a specific inhibitor of Cdc42 was shown to functionally rejuvenate aged HSCs, increase the percentage of polarized cells in an aged HSC population, and