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PubMed PMID: 25088224
42-dodecamethyl-15
is a non-nucleoside reverse transcriptase inhibitor potentially for the treatment of HIV infection
A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses
Crizotinib Hydrochloride - CAS# 1415560-69-8 Size:Solid 2 mg PubMed PMID: 25088224Crizotinib (PF 02341066) hydrochloride (Xalkori) inhibits tyrosine phosphorylation of c Met and nucleophosmin (NPM) anaplastic lymphoma kinase (ALK) with IC50 of of 11 nM and 24 nM in cell based assays, respectively. Crizotinib hydrochloride is also a potent ROS1 inhibitor with Ki less than 0. 025 nM. Crizotinib induces autophagy through inhibition of the STAT3 pathway in multiple lung cancer cell lines. Product information CAS Number: 1415560 69 8
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