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NS11394 has a significantly reduced side effect profile in rat (sedation
4]oxazepin-4(5H)-yl)propan-1-one
InChiKey: KPTMSQHTGZMEFU-UHFFFAOYSA-N
9-tetrahydro-1H-pyrido[3
D-Sphingosine - CAS# 123-78-4 Catalog No.:M6801-10 NS11394 has a significantly reducedD Sphingosine, CAS No. 123 78 4, is formed primarily from the breakdown of ceramide. Sphingosine inhibits protein kinase C and phosphatidic acid phosphohydrolase. D sphingosine, a lipid possessing the same hydrophobic base as ceramide but without a carbohydrate residue, efficiently blocked this glycolipid antigen presentation both in vitro and in spinal cords of EAE mice, and significantly decreased IL 17 and ameliorated the pathological symptoms.