TAK-243 (MLN7243) - Ubiquitin Activating Enzyme (UAE) Inhibitor. CAS# 1450833-55-2 110 LDN-214117 demonstrates selective inhibition of

LDN-214117 demonstrates selective inhibition of ALK2 and ALK1 in preference to ALK3 kinase activity

Smiles: CN(C)CC1=CC(OC)=C(C=C1OC)C1=CN(C)C(=O)C2=CN=CC=C21

InChi: InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H

805 - 808 (2009)

TAK-243 (MLN7243) - Ubiquitin Activating Enzyme (UAE) Inhibitor. CAS# 1450833-55-2 110 LDN-214117 demonstrates selective inhibition ofTAK 243 (MLN7243), CAS No. 1450833 55 2, is a potent, selective and cell permeable small molecule inhibitor of the ubiquitin activating enzyme (UAE) at nM range. The ubiquitin activating enzymes, found more active in cancer cells than in normal healthy cells, catalyze the first step in ubiquitination reaction, targeting a protein for degradation via proteasome. TAK 243 treatment caused depletion of cellular ubiquitin conjugates, resulting in