Z-VDVAD-FMK 21843 Smiles: CC(C)(CC1CC2=CC=CC=C2C1)NC[C@@H](O)COC1=CC(CCC(O)=O)=CC=C1C#N

Smiles: CC(C)(CC1CC2=CC=CC=C2C1)NC[C@@H](O)COC1=CC(CCC(O)=O)=CC=C1C#N

Formula: C24H31N3O3

2 macrophages activated with LPS (10 μg/mL) and INF (50 μg/mL)

Diphenylterazine injections into untransfected BALB/c mice do not yield any background emission

Z-VDVAD-FMK 21843 Smiles: CC(C)(CC1CC2=CC=CC=C2C1)NC[C@@H](O)COC1=CC(CCC(O)=O)=CC=C1C#NJurkat T lymphocytes treated with an irreversible caspase 2 inhibitor, benzyloxycarbonyl Val Asp(OMe) Val Ala Asp(OMe) fluoromethyl ketone (Z VDVAD FMK), or stably transfected with pro caspase 2 antisense (Casp 2 AS) are refractory to cytochrome c release stimulated by etoposide1. When etoposide induced activation of pro caspase 2 is subverted by Z VDVAD FMK or stable transfection of pro caspase 2 antisense, cytochrome c release and other