EZH2-IN-4 7361 InChi: InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-18-7-12(3-5-16(18)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9

InChi: InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-18-7-12(3-5-16(18)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9

CCOC(=O)C[N+]1(C)C[C@@H](CC1)OC(=O)[C@@](O)(C1CCCC1)C1C=CC=CC=1

Goldenberg E

2014 Oct 1

EZH2-IN-4 7361 InChi: InChI=1S/C25H22O10/c1-32-17-6-11(2-4-14(17)28)24-20(10-26)33-18-7-12(3-5-16(18)34-24)25-23(31)22(30)21-15(29)8-13(27)9-19(21)35-25/h2-9EZH2 IN 4 is an orally active, potent EZH2 inhibitor with IC50s of 0. 923 nM and 2. 65 nM against wild type (WT) 5 membered (5 mer) EZH2 and mutant 5 mer EZH2, respectively. EZH2 IN 4 has anti cancer activity. Product information CAS Number: 2088132 99 2 Molecular Weight: 511. 72 Formula: C29H41N3O3S Chemical Name: 7 ((4, 6 dimethyl 2 oxo 1, 2 dihydropyridin 3 yl)methyl) 2 ((R) 1 ((1r, 4R) 4 (3 methoxyazetidin 1 yl)cyclohexyl)ethyl) 3 methyl 4, 5, 6,