BMS-754807 - CAS# 1001350-96-4 cone Smiles: CC1OC(=O)OC=1CN1CCN(CC1)C1=CC2=C(C=C1F)C(=O)C(=C1SC(C)N21)C(O)=O

Smiles: CC1OC(=O)OC=1CN1CCN(CC1)C1=CC2=C(C=C1F)C(=O)C(=C1SC(C)N21)C(O)=O

GR 68755 ((Z)-2-butenedioate)

Smiles: CC1N=C(C)C(=NC=1C(N)=O)C1C=CC(=CC=1)C1CCC(CC(O)=O)CC1

mucus metaplasia

BMS-754807 - CAS# 1001350-96-4 cone Smiles: CC1OC(=O)OC=1CN1CCN(CC1)C1=CC2=C(C=C1F)C(=O)C(=C1SC(C)N21)C(O)=OBMS 754807 is an orally bioavailable antagonist of human insulin like growth factor type I receptor (IGF 1R) with potential antineoplastic activity. IGF 1R antagonist BMS 7548077 binds to IGF 1R, preventing IGF 1 ligand binding and activation of IGF 1R mediated signaling pathways; inhibition of IGF 1R mediated signaling pathways may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF 1R is a receptor