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gov/books/NBK154499/ PubMed PMID: 24027804
7 mg/kg after oral treatment
It acts by suppressing X-linked inhibitor of apoptosis protein (XIAP) and survivin levels
1'-biphenyl]-3-yl]propanoic acid hydrochloride
MK-4827 Hydrochloride l blocker gov/books/NBK154499/ PubMed PMID: 24027804Niraparib, also know as MK 4827, is an inhibitor of poly (ADP ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base excision repair (BER) pathway. Product information CAS Number: 1038915 64 8 Molecular Weight: 356. 85 Formula:
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