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Epub 2012 Oct 24
It shows >63-fold selectivity for Chk1 over Chk2 and a panel of 84 other kinases
JHU 37160 inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons
4-quinazolinediamine
Proparacaine Hydrochloride - CAS# 5875-06-9 cylate Epub 2012 Oct 24Proparacaine Hydrochloride is the hydrochloride salt form of proparacaine, a benzoic acid derivative with local anesthetic property. It is used as a topical ophthalmic anesthetic. Proparacaine hydrochloride stabilizes the neuronal membrane by binding to and inhibiting voltage gated sodium channels, thereby inhibiting sodium ion influx required for the initiation and conduction of impulses within the neuronal cell, and resulting in a loss of sensation.
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