NB-360 Size:Contact [email protected] for quotation promotes oligodendrocyte precursor cell (OPC)

promotes oligodendrocyte precursor cell (OPC) differentiation in a dose-dependent manner

InChiKey: YWZUFJFIXFJKBD-XPWALMASSA-N

6R)-5-hydroxy-4-methoxy-6-methyloxan-2-yl]oxy}-9a

Smiles: CCCCS(=O)(=O)NC1=NC=NC(OCCOC2N=CC(Br)=CN=2)=C1C1C=CC(Br)=CC=1

NB-360 Size:Contact [email protected] for quotation promotes oligodendrocyte precursor cell (OPC)NB 360 is a potent, brain penetrable, and orally bioavailable dual BACE1 BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB 360 shows a superior pharmacological profile and robust reduction of amyloid and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB 360 can completely block the progression of A deposition in the brains of APP transgenic mice. NB 360 shows excellent selectivity over the related aspartyl