ML228 - HIF Pathway Activator. CAS# 1357171-62-0 0161 Hammitzsch A

Name: ML228 - HIF Pathway Activator. CAS# 1357171-62-0 0161 Hammitzsch A
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Description

Hammitzsch A

Pinometostat

290(22):13641-53

A chemical platform for improve induction of human iPS cells

ML228 - HIF Pathway Activator. CAS# 1357171-62-0 0161 Hammitzsch AML228, CAS No. 1357171 62 0, is a hypoxia inducible factor (HIF) pathway activator with an EC50 at ~1. 23 M in HRE gene reporter assay and ~1. 4 M in HIF 1 nuclear translocation assay. It does not inhibit the proteasome, but activates HIF stabilization and nuclear translocation, and induces expression of a HIF specific downstream gene (VEGF). It has no apparent toxicity below 30 M and appeared to be an iron chelator, independently of PHD. HIFs are

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