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Chemical Name: 2-[5-(1-{15-[(2
a protein kinase mutated in Parkinson's disease
respectively CCT018159 is an inhibitor of Hsp90
CCG50014 (10
MRTX1133 574rocortin II human Chemical Name: 2-[5-(1-{15-[(2MRTX1133 is a potent and selective KRAS G12D inhibitor. MRTX1133 targets the KRAS G12D protein in both active and inactive states. In preclinical studies, MRTX1133 exhibited a long half life, an ability to bind the KRAS G12D protein in both active and inactive states, and selective inhibition of KRAS G12D mutant cancer cells. In G12D mutant tumor models, MRTX1133 showed dose dependent selective inhibition of the KRAS pathway and tumor regression.
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