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Formula: C21H22N4O2
Mcl-1 inhibitor 6 (3 mg/kg with IV or 10 mg/kg with PO) has a T1/2 of 2
Smiles: CC(C)C1C=CC(C=O)=CC=1
180:253-267
AS-99 15723 Formula: C21H22N4O2AS 99 is a first in class, potent and selective ASH1L histone methyltransferase inhibitor (IC50= 0. 79 M, Kd= 0. 89 M) with anti leukemic activity. AS 99 blocks cell proliferation, induces apoptosis and differentiation, downregulates MLL fusion target genes, and reduces the leukemia burden in vivo. Product information CAS Number: 2323623 93 2 Molecular Weight: 593. 68 Formula: C27H30F3N5O3S2 Chemical Name:
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