SIS3 HCl - CAS# 521984-48-5 225 InChi: InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9

InChi: InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9

1(2):59-63

2*1H2/t11-

Modulation of innate and adaptive immune responses by tofacitinib (CP-690

SIS3 HCl - CAS# 521984-48-5 225 InChi: InChI=1S/C34H44N4O4/c1-5-38(29-10-14-41-15-11-29)32-20-28(27-8-6-26(7-9-27)22-37-12-16-42-17-13-37)19-30(25(32)4)33(39)35-21-31-23(2)18-24(3)36-34(31)40/h6-9SIS3 HCl, CAS No. 521984 48 5, a novel specific inhibitor of Smad3, inhibits TGF and activin signaling by suppressing Smad3 phosphorylation without affecting the MAPK p38, ERK, or PI3 kinase signaling pathways. Product information CAS Number: 521984 48 5 Molecular Weight: 489. 99 Formula: C28H28ClN3O3 Synonym: (E) SIS3 Chemical Name: (2E) 1 (6,7 dimethoxy 1,2,3,4 tetrahydroisoquinolin 2 yl) 3 {1 methyl 2 phenyl 1H pyrrolo[2,3 b]pyridin 3 yl}prop 2 en