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21(3):234-40
4-dimethylpentanamido]-3-[1-(methoxycarbonyl)-1H-indol-3-yl]propanamido]hexanoic acid
GSK-3β inhibitor 2 can cross the blood-brain barrier
3-benzodiazole hydrochloride
MS31 trihydrochloride tenol sodium 21(3):234-40MS31 trihydrochloride is a potent, highly affinity and selective fragment like methyllysine reader protein spindlin 1 (SPIN1) inhibitor. MS31 trihydrochloride potently inhibits the interactions between SPIN1 and H3K4me3 (IC50=77 nM, AlphaLISA; 243 nM, FP). MS31 trihydrochloride selectively binds Tudor domain II of SPIN1 (Kd=91 nM). MS31 trihydrochloride potently inhibits binding of trimethyllysine containing peptides to SPIN1, and is not toxic to
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