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This agent has little or no affinity for serotonin type 3 (5-HT3)
Treatment with VP-16 and ADM reduced metastasis formation by SBC-3 cells
In: Probe Reports from the NIH Molecular Libraries Program
Formula: C52H60F2N8O7
CHIR-98014 - CAS# 252935-94-7 Size:Solid 2 mg This agent has little orCHIR98014, also known as CT 98024, is a reversible, cell permeable inhibitor of GSK3 and GSK3 (IC50 = 0. 65 and 0. 58 nM, respectively). It is inactive against a series of other serine threonine or tyrosine kinases. Through its effects on GSK3, CHIR98014 stimulates glycogen synthase in cells (EC50 = 106 nM), potentiates insulin dependent glucose transport in isolated muscle strips, and improves glucose disposal in diabetic animals. CHIR98014 also