SB 242084 Catalog No.:M21140-C Chemical Name: 4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1

Chemical Name:  4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1

10-oxygenated protoberberine

It is used to treat many infections including treatment of respiratory

whereas other transformed and normal human cells are several orders of magnitude less sensitive

SB 242084 Catalog No.:M21140-C Chemical Name: 4-amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1SB 242084 is a 5 HT2C receptor antagonist(pKi=9. 0) that displays 158 and 100 fold selectivity over 5 HT2A and 5 HT2B receptors respectively. IC50 value: 9. 0(pKi) Target: 5 HT2C antagonistin vitro: SB 242084 had over 100 fold selectivity over a range of other 5 HT, dopamine and adrenergic receptors. In studies of 5 HT stimulated phosphatidylinositol hydrolysis using SH SY5Y cells stably expressing the cloned human 5 HT2C receptor, SB 242084 acted as