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It also inhibits asparaginyl-hydroxylase factor inhibiting HIF (FIH) and is useful for controlling excess collagen deposition in pathological fibrosis
3-isobutyl-4-[4-(3-methyl-2-butenyloxy)phenyl]furan-2
2-dihydroxyethyl]-3-methoxy-1
Formula: C26H26O4
GNE-616 emsirolimus It also inhibits asparaginyl-hydroxylase factorGNE 616 is a highly potent, metabolically stable, orally bioavailable, and subtype selective Nav1. 7 inhibitor (Ki of 0. 79 nM and Kd of 0. 38 nM for hNav1. 7) for the treatment of chronic pain. GNE 616 shows >1000 nM Kd and >2500 fold selectivity over hNav1. 1, hNav1. 3, hNav1. 4, and hNav1. 5. Selectivity over hNav1. 2 and hNav1. 6 is more modest at 31 and 73 fold, respectively. Product information CAS Number: 2349371 81 7 Molecular Weight: 537. 53
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