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Chemical Name: trimagnesium(2+) bis((2Z
PLK1 inhibition leads to pharmacodynamic pHisH3 modulation and significant antitumor activity in multiple DLBCL models
Smiles: [2H]C1=C(OCCC2=CC=C(CC)C=N2)C([2H])=C([2H])C(CC2SC(=O)NC2=O)=C1[2H]
Addition of the 12/15-LO inhibitor
PF-3758309 dihydrochloride ergocristine mesylate Chemical Name: trimagnesium(2+) bis((2ZPF 3758309 dihydrochloride is a potent, orally available, and reversible ATP competitive inhibitor of PAK4 (Kd= 2. 7 nM; Ki=18. 7 nM). PF 3758309 dihydrochloride has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation. Product information Molecular Weight: 563. 55 Formula: C25H32Cl2N8OS Chemical Name: N [(1S) 2 (dimethylamino)