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Smiles: COC1C=C(C=CC=1O)C=CC(=O)CC(=O)C=CC1C=CC(O)=CC=1
6-tetrahydroxyhexanal hydrochloride is an endogenous metabolite
with IC50s of 8 and 6 µM at 48 and 72 h
NS-398 suppresses writhing reactions induced by acetic acid with an ED50 of 8
BI-9627 Catalog No.:M21408-C Smiles: COC1C=C(C=CC=1O)C=CC(=O)CC(=O)C=CC1C=CC(O)=CC=1BI 9627 is potent sodium hydrogen exchanger isoform 1 (NHE1) inhibitor, with IC50s of 6 and 31 nM in intracellular pH recovery (pHi) and human platelet swelling assays, respectively. BI 9627 displays >30 fold selectivity against NHE2 and with no measurable inhibitory activity against the NHE3 isoform. BI 9627 shows low DDI (drug drug interaction) potential, excellent pharmacokinetics in rat and dog, and remarkably potent activity in the isolated heart