BS-181 dihydrochloride enzamine Hydrochloride Chemical Name: 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3

Chemical Name: 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3

Geraghty RJ

C[C@@H]1CN[C@@]2(CC1)O[C@H]1C[C@H]3[C@@H]4CC[C@H]5C[C@@H](O)CC[C@]5(C)[C@H]4CC[C@]3(C)[C@H]1[C@@H]2C

CAS Number: 638-94-8

BS-181 dihydrochloride enzamine Hydrochloride Chemical Name: 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3BS 181 dihydrochloride is a potent and selective CDK7 inhibitor (IC50=21 nM) than Seliciclib (HY 30237). BS 181 is also against CDK2, CDK5 and CDK9 with IC50 values of 880 nM, 3000 nM and 4200 nM, respectively (fails to block CDK1, 4 and 6). BS 181 dihydrochloride inhibits a panel of cancer cells growth (IC50=11. 5 M 37. 3 M) and induces cell apoptosis. BS 181 dihydrochloride has the potential for the research of cancer therapy. Product information