Z-VAD(OMe)-FMK 539 HCl InChi: InChI=1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5

InChi: InChI=1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5

Lenalidomide and pomalidomide inhibits autoubiquitination of CRBN in HEK293 T cells expressing thalidomide-binding competent wild-type CRBN

Smiles: C[C@H](C1=CC2=C(C(=CC=C2C=C1)OC1CCC(CC1)C(F)(F)F)C(F)(F)F)N1C2CC(CC1CC2)C(O)=O

Smiles: OC(=O)C1=CC=CC=C1C(=O)C1=CC(C2C=CC=CC=2)=C(O)C=C1

Z-VAD(OMe)-FMK 539 HCl InChi: InChI=1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5Z VAD FMK is a cell permeable, irreversible pan caspase inhibitor. Z VAD FMK inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0. 0015 5. 8 mM). Z VAD(OMe) FMK is an ubiquitin carboxy terminal hydrolase L1 (UCHL1) inhibitor. Z VAD(OMe) FMK irreversibly modifies UCHL1 by targeting the active site of UCHL1. Product information CAS Number: 187389 52 2 Molecular Weight: 467. 49 Formula: C22H30FN3O7 Synonym: Z VAD(OMe) FMK