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CDDO-dhTFEA Catalog No.:M28476-C Cdk4/Cyclin D1

SKU: 82173025077

4.2
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Description

Cdk4/Cyclin D1

Chemical Name: 8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(oxan-4-yl)-9H-purine

SU-14813 maleate

InChi: InChI=1S/C39H38ClN8O6S/c1-20-21(2)55-39-32(20)34(23-11-13-25(40)14-12-23)43-27(35-46-45-22(3)47(35)39)18-31(51)41-17-6-4-5-10-29(49)42-19-24-8-7-9-26-33(24)38(54)48(37(26)53)28-15-16-30(50)44-36(28)52/h7-9

CDDO-dhTFEA Catalog No.:M28476-C Cdk4/Cyclin D1CDDO dhTFEA (RTA dh404) is a synthetic oleanane triterpenoid compound which potently activates Nrf2 and inhibits the pro inflammatory transcription factor NF B. CDDO dhTFEA restores hypertension (MAP), increases Nrf2 and expression of its target genes, attenuates activation of NF B and transforming growth factor pathways, and reduces glomerulosclerosis, interstitial fibrosis and inflammation in the chronic kidney disease (CKD) rats. Product

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