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incorporates an E3 ligase ligand plus a PEG2 linker with terminal acid ready for conjugation to a target protein ligand
11bR)-3-hydroxy-10
1042/BJ20150658
Pyridostatin (RR82) is a G-quadruplex DNA stabilizing agent (Kd=490 nM)
Udenafil - CAS# 268203-93-6 119 incorporates an E3 ligase ligandUdenafil is an inhibitor of phosphodiesterase 5 (PDE5). In vivo, udenafil increases lung cGMP levels, attenuates the development of compensatory right ventricular hypertrophy, and reduces pulmonary arterial wall thickening. It increases creatine clearance and decreases blood urea nitrogen (BUN) and serum malondialdehyde (MDA) levels in a rat model of renal ischemia reperfusion injury. Udenafil also induces penile erections in conscious rabbits and in
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