Febuxostat 5132 so it has IC50 >1

so it has IC50 >1 µM for inhibiting demthylation of H3K4 in U2OS human osteosarcoma cell line and in human breast adenocarcinoma MCF7 tumor cell proliferation assay

SAR439859 shows promising antitumor activity in breast cancer mice xenograft models

possible use for in vivo study (IP dosing 15-50 mg/kg

Wu-Hsieh BA

Febuxostat 5132 so it has IC50 >1Febuxostat, also known as Uloric and TMX 67, is a xanthine oxidase inhibitor used to treathyperuricemia and chronic gout. Product information CAS Number: 144060 53 7 Molecular Weight: 316. 37 Formula: C16H16N2O3S Synonym: TEI 6720 TMX 67 Uloric FBX Chemical Name: 2 [3 cyano 4 (2 methylpropoxy)phenyl] 4 methyl 1,3 thiazole 5 carboxylic acid Smiles: CC1N=C(SC=1C(O)=O)C1=CC(C#N)=C(C=C1)OCC(C)C InChiKey: BQSJTQLCZDPROO UHFFFAOYSA N InChi: InChI=1S