WS3 - β Cell Proliferation Inducer. CAS# 1421227-52-2 60302 Genome-wide analysis in Jurkat T-ALL

Genome-wide analysis in Jurkat T-ALL cells shows that THZ1 disproportionally affects transcription of RUNX1 and suggests that sensitivity to THZ1 may be due to vulnerability conferred by the RUNX1 super-enhancer and the key role of RUNX1 in the core transcriptional regulatory circuitry in these tumor cells

[Epub ahead of print] PubMed PMID: 26791484

2013 Dec 24

Many tumors become addicted to autophagy for survival

WS3 - β Cell Proliferation Inducer. CAS# 1421227-52-2 60302 Genome-wide analysis in Jurkat T-ALLWS3, CAS No. 1421227 52 2, is a highly potent and selective small molecule that promotes pancreatic cell and RPE cells expansion, identified by a high throughput, cell based screening. It can induce proliferation of mouse R7T1 cells with an EC50 ~0. 074 M, and expansion of primary rat and human cells in dissociated and intact islet format with similar EC50. WS3 can also reversibly proliferate primary RPE cells isolated from fetal and adult human