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and inhibits cell migration in NSCLC cells
It has binding affinity to the human GPR40 receptor with Ki of 38 nM and the rat GPR40 receptor with Ki of 140 nM
Arrendale RF
[Epub ahead of print] PubMed PMID: 20502937
Ku-55933 - CAS# 587871-26-9 0193 and inhibits cell migration inKU 55933, CAS No. 587871 26 9, is an ATM inhibitor. KU 55933 blocks the phosphorylation of Akt induced by insulin and insulin like growth factor I in cancer cells that exhibit abnormal Akt activity. Moreover, KU 55933 inhibits cancer cell proliferation by inducing G(1) cell cycle arrest. It does so through the downregulation of the synthesis of cyclin D1, a protein known to be elevated in a variety of tumors. In addition, KU 55933 treatment during