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11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6
C2HF3O2/c24-9-16(35)30-11(3-1-5-28-23(26)27)19(39)29-10-17(36)31-12(8-18(37)38)20(40)32-13(7-15(25)34)21(41)33-6-2-4-14(33)22(42)43
In vivo experiments using the KM12-bearing mouse xenograft model shows that DS-6051b induced tumor shrinkage at a ≥50 mg/kg or higher treatment dose without significant body weight loss
Smiles: CC1N=CSC=1C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCCCCCCCC(O)=O)C(C)(C)C)C=C1
PF-3644022 Catalog No.:M12254-2 11(2)29)8-13-19(16)26(34)21-20(24(13)32)23(31)12-5-4-6-15(36-3)18(12)25(21)33/h4-6PF 3644022 is a potent, selective, orally active and ATP competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5. 2 nM and a Ki of 3 nM. PF 3644022 also inhibits MK3 and p38 regulated activated kinase (PRAK) with IC50s of 53 nM and 5. 0 nM, respectively. PF 3644022 potently inhibits TNF production and has anti inflammatory effect. Product information CAS Number: 1276121 88 0 Molecular Weight: 374. 46 Formula: C21H18N4OS Chemical Name: (15R) 15 methyl 5
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