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Petrassi HM
also known as RXDX-101 and NMS-E628
and 100 mg/kg
A single topical application of Lotamilast significantly inhibits spontaneous scratching during 1–2 h after application in mice with chronic dermatitis
JW67 246MS 299897 Petrassi HMJW67 inhibits the canonical Wnt signaling with an IC50 of 1. 17M. JW67 affects the multiprotein complex consisting of catenin GSK 3 AXIN APC CK1 that rapidly reduces active catenin with a subsequent downregulation of Wnt target genes. JW67 also inhibits colorectal cancer cell growth. Product information CAS Number: 442644 28 2 Molecular Weight: 394. 38 Formula: C21H18N2O6 Chemical Name: trispiro[indole 3,2': 5',5'' bis([1,3]dioxane) 2'',3''' indole]
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