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Smiles: CN1CCN(CC1)C1=CC2NC(=NC=2C=C1)C1=CC2NC(=NC=2C=C1)C1=CC(=CC=C1)OCCCC(O)=O
27-/m1/s1/i1D3
2019 Feb 14
It selectively inhibits PMA-induced NF-κB activation
FC 11 - CAS# 2271035-37-9 054 Hydrochloride Smiles: CN1CCN(CC1)C1=CC2NC(=NC=2C=C1)C1=CC2NC(=NC=2C=C1)C1=CC(=CC=C1)OCCCC(O)=OFC 11 is a highly potent focal adhesion kinase (FAK) PROTAC Degrader (DC50 values are 40 to 370 pM depending on cell line), which is composed of the FAK inhibitor PF 562217 joined by a linker to the cereblon binding ligand Pomalidomide (Cat. No. 6302). The effects of FC 11 are reversible upon compound wash out. FC 11 also degrades autophosphorylated FAK (pFAKtyr397), displaying near complete degradation after 3 hours at 100 nM in TM3 cells. Product
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