EPZ-5676 - DOT1L inhibitor. CAS# 1380288-87-8 60160 The inhibition of USP7 is

The inhibition of USP7 is predicted to destabilize HDM2 and stabilize p53

Pipalia NH

(2015) Chem Biol

290(22):13641-53

EPZ-5676 - DOT1L inhibitor. CAS# 1380288-87-8 60160 The inhibition of USP7 isEPZ 5676, CAS No. 1380288 87 8, is a highly potent and selective inhibitor of DOT1L methyltransferase with Ki of 70 pM, selectively blocking the binding of the cofactor, S adenosylmethionine. It inhibits proliferation of MLL AF4 rearranged cell line MV4 11 with an IC50 of 9 nM. It reduces H3K79 dimethylation with a cellular IC50 of 2. 6 nM in MV4 11 cells. EPZ 5676 has over 10, 000 fold selectivity against other HMTs. Its superior potency is