Thailanstatin A - CAS# 1426953-21-0 Catalog No.:M17320-C CAS Number: 65678-07-1

CAS Number: 65678-07-1

Rab2 and Rab7

addition of 10 mM D-α-Hydroxyglutaric acid results in a partial (33%) inhibition of TET2 and addition of 50 mM D-α-Hydroxyglutaric acid results in more inhibition (83%) of TET2

adding 10 mM CuCl2 stock solution to give a final copper concentration of 100 μM

Thailanstatin A - CAS# 1426953-21-0 Catalog No.:M17320-C CAS Number: 65678-07-1Thailanstatin A is an ultra potent inhibitor of eukaryotic RNA splicing (IC50=650 nM). Thailanstatin A exerts effects via non covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the spliceosome and shows low nM to sub nM IC50s against multiple cancer cell lines. Thailanstatin A, a payload for ADCs, is conjugated to the lysines on trastuzumab yielding linker less ADC. Product information CAS Number: 1426953 21 0 Molecular Weight: 535. 63